Seminars in Molecular Biology and Genetics, MBGL408

Friday, May 07, 2021 at 3:30 pm

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Peptide-based Nanomaterials for Tissue Engineering and Immuno-engineering

By Dr. Rashad Mammadov

Rashad Mammadov received his Bachelor of Science degree in Molecular Biology & Genetics from Middle East Technical University, Ankara, Türkiye (2006). Then he moved to Bilkent University, Institute of Materials Science & Nanotechnology (UNAM) for his graduate studies. He obtained his master’s degree for his work on immunostimulatory DNA nanoparticles. His PhD work concentrated on peptide amphiphile nanomaterials and their applications to tissue engineering and immuno-engineering. His findings from PhD studies have been published by several scientific journals such as Biomacromolecules and Scientific Reports. After a year of postdoctoral work in the same group, he moved to Virginia, US. Having worked as a research associate at the University of Virginia, he learned and applied Crispr-Cas9 technology for genetic and epigenetic editing purposes. He also developed an interest in chromatin folding and epigenetic regulation in that period which he aims to pursue in the future. Currently, Dr. Mammadov is affiliated with Bartin University, Department of Molecular Biology and Genetics.

Abstract 

There has been considerable emphasis on nanotechnology in recent decades about the design of biomaterials and engineering of human tissues. This has increased awareness of bioengineers on physical and chemical aspects of the material – tissue interaction. Seeing the subject from the interface of various sciences is a matter of infinite hope that may eventually bring necessary insights to treat incurable diseases. Accordingly, researchers try to uncover the physical and chemical principles that shape the output of “central dogma” and use that knowledge to develop more effective materials.

In this talk, I will give examples from my research, where chemical and physical signals were employed in the design of bioactive materials. In the first example, peptide-based nanofibers were evaluated as a tool for tissue engineering. Decorating nanofibers with simple chemical functional groups inspired from extracellular matrix molecules increased growth factor binding to nanofibers as well as new blood vessel formation. Several in vivo works demonstrated their potential in various tissue engineering settings, such as wound healing. In the second example, peptide nanofibers and nanospheres were considered as a carrier of pathogenic molecular patterns. I will show that immune response to these pathogenic signals differs significantly related to the shape of their carrier.