Seminars in Molecular Biology and Genetics MBGL408
Friday, April 16, 2021 at 12:00
‘Impact of Bisphenol A Concentrations on Genes Associated with
Oocyte Maturation in Cumulus Cells of POR Response Women’
By Dr. Somaye Aftab Savad
PhD of Molecular Genetics 2020, Islamic Azad university of Tehran IRAN, Science and Research Branch, Thesis Title: Effect of Bisphenol A on alterations of ICAM-1 and HLA-G genes Expression and DNA methylation profiles in Cumulus Cells of Infertile Women with Poor Response to Ovarian Stimulation. Master of Molecular Genetics 2014, Islamic Azad university of Zanjan IRAN, Science and Research Branch, Thesis Title: EGFR, ERK, MEK genes expression Level in Cumulus cells of PCOS women compared with healthy women. Bachelor of Molecular Genetics 2012, Islamic Azad University of Pishva.
The term poor response to ovarian stimulation (POR) typically refers to woman with a reduced ovarian reserve or poor ovarian response to exogenous gonadotropin stimulation. In fact, the POR or the cycle without ovulation is a cycle in which the ovary is unable to release the oocyte. Recently, POSEIDON criteria have been used to diagnose POR, including age, Anti Müllerian Hormone (AMH) dose, Antra Follicle Count (AFC), and oocyte number. The consequential complications of POR are intrinsic ovarian resistance to gonadotropin stimulation, reduced ovarian reserve, ovulation and oocyte maturation disorder. Reduced ovarian reserve is defined as the impaired fertility ability leading to infertility. In fact, excessive use of plastics objects in the human life has been proposed as one of the causes of creating POR in women. Indeed, excessive use of plastics to store hot food and drinks can cause various diseases. Polycarbonate is a type of plastic containing BisphenolA (BPA). Over time, when plastic is heated or exposed to acidic or alkaline substances, it breaks down and BPA attaches to food and drink, so that it can enter the body. BPA, by mimicking sex hormones, can disrupt the endocrine system, hormones, hormonal signaling pathways and gene expression. BPA even in small amounts may interfere with the ovulation, ovarian response, oocyte maturation, pregnancy and genes function. In fact, lifestyle habit plays a key role in regulating ovarian response, oocyte maturation and genes expression. Gene’s expression alteration in POR patients is a condition damaging oocyte developmental, resulting in reduced rates of fertilization, embryonic development, and implantation.